Beilstein J. Org. Chem.2013,9, 2358–2366, doi:10.3762/bjoc.9.271
consisting of ozonolysis and reductive dehydroxylation provided the indolizidine derivative 5, which completed the formal enantioselective total synthesis of pumiliotoxins 251D and 237A.
Keywords: enantioselective synthesis; Grignard reagent; pumiliotoxin237A; pumiliotoxin 251D; reductive dehydroxylation
alkaloids of dendrobatid poison frogs [4][5]. Forthermore, from the extracts of an unidentified Scheloribates sp. of mites, pumiliotoxin237A (3) was detected as a minor component [6].
That the wide range of biological activities possessed by these molecules have attracted much attention of synthetic
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Graphical Abstract
Figure 1:
Structures of some pumiliotoxins and an advanced intermediate.